anti-survivin TCR, pLXSN(TCR-L105)

The vector of anti-survivin T cell receptor (TCR) is constructed for the engineering of T cell to target Human survivin. The T cells are genetically modified through transduction with a retroviral vector expressing survivin-specific T cell receptor. And the vector product was designed for the treatment of diseases involving malignant cells expressing survivin.


Details


Target
survivin
Target Species
Human
Epitope
LMLGEFLKL
Format
Non-modified TCR
HLA
HLA-A*0201
Targeting Diseases
Diseases involving malignant cells expressing survivin
Vector Name
pLXSN
Vector Length
6714-6688bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
baculoviral IAP repeat containing 5
Official Symbol
BIRC5
Gene ID
UniProt ID
Synonyms
SSX; HD21; CT5.2; CT5.2A; HOM-MEL-40; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Synovial sarcoma
Introduction
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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