anti-Tat TCR, pGMT7(TCR-L108)

The vector of anti-Tat T cell receptor (TCR) is constructed for the engineering of T cell to target HIV Tat. The T cells are genetically modified through transduction with a retroviral vector expressing Tat-specific T cell receptor. And the vector product was designed for the treatment of AIDS.


Details


Target
Tat
Target Species
HIV
Epitope
ITKGLGISYGR
Format
Non-modified TCR
HLA
HLA-A68
Targeting Diseases
AIDS
Vector Name
pGMT7
Vector Length
3111bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
p14
Official Symbol
tat
Gene ID
UniProt ID
Synonyms
p14; Protein Tat; Transactivating regulatory protein; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; AIDS; HIV
Introduction
HIV1 tat (Transactivator of Transcription) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, tat is a powerful transactivator of gene expression which acts by inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes on to the viral LTR.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Viral Infection

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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