anti-telomerase catalytic subunit protein TCR, pGMT7(TCR-L112)

The vector of anti-telomerase catalytic subunit protein T cell receptor (TCR) is constructed for the engineering of T cell to target Human telomerase catalytic subunit protein. The T cells are genetically modified through transduction with a retroviral vector expressing telomerase catalytic subunit protein-specific T cell receptor. And the vector product was designed for the treatment of cancer.


Details


Target
telomerase catalytic subunit protein
Target Species
Human
Epitope
VYGFVRACL
Format
Non-modified TCR
HLA
HLA-A*0201
Targeting Diseases
Cancer
Vector Name
pGMT7
Vector Length
3111bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
telomerase reverse transcriptase
Official Symbol
TERT
Gene ID
UniProt ID
Synonyms
TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Cancer
Introduction
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Fax: 1-631-207-8356
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