anti-tuberculosis antigen TCR, pMX-IRES-GFP(TCR-L115)

The vector of anti-tuberculosis antigen T cell receptor (TCR) is constructed for the engineering of T cell to target T. bacillus tuberculosis antigen. The T cells are genetically modified through transduction with a retroviral vector expressing tuberculosis antigen-specific T cell receptor. And the vector product was designed for the treatment of tuberculosis.


Details


Target
tuberculosis antigen
Target Species
T. bacillus
Targeting Diseases
Tuberculosis
Vector Name
pMX-IRES-GFP
Vector Length
6000bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
Mycobacterium tuberculosis
Official Symbol
M. tuberculosis
Synonyms
tuberculosis; M. tuberculosis; Mycobacterium tuberculosis; tubercle bacillus; tuberculosis antigen; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector ; Tuberculosis
Introduction
Mycobacterium tuberculosis is an obligate pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of most cases of tuberculosis.[2] First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface (primarily due to the presence of mycolic acid), which makes the cells impervious to Gram staining; M. tuberculosis can appear Gram negative and Gram positive in clinical settings.[3] The Ziehl-Neelsen stain, or acid-fast stain, is used instead. The physiology of M. tuberculosis is highly aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, it infects the lungs. The most frequently used diagnostic methods for tuberculosis are the tuberculin skin test, acid-fast stain, and chest radiographs.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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