anti-tyrosinase TCR, pMP71(TCR-L120)

The vector of anti-tyrosinase T cell receptor (TCR) is constructed for the engineering of T cell to target Human tyrosinase . The T cells are genetically modified through transduction with a retroviral vector expressing tyrosinase -specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
tyrosinase
Target Species
Human
Epitope
YMDGTMSQV
Format
Codon optimized TCR
HLA
HLA-A2
Targeting Diseases
Melanoma
Vector Name
pMP71
Vector Length
3817bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
tyrosinase
Official Symbol
TYR
Gene ID
UniProt ID
Synonyms
VSIV8; VSIV-8; Vesicular Stomatitis Virus Nucleoprotein (52 - 59); Vesicular Stomatitis Virus Nucleoprotein; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector
Introduction
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


Carcinoma

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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