anti-vpr TCR, pMSGV1(TCR-L122)

The vector of anti-vpr T cell receptor (TCR) is constructed for the engineering of T cell to target HIV vpr. The T cells are genetically modified through transduction with a retroviral vector expressing vpr-specific T cell receptor. And the vector product was designed for the treatment of ADIS.


Details


Target
vpr
Target Species
HIV
Epitope
AIIRILQQL
Format
Affinity enhanced
HLA
HLA-A2
Targeting Diseases
ADIS
Vector Name
pMSGV1
Vector Length
6700-8070bp
Vector Type
retroviral vector
Antibody Host
Human

Target


Gene Name
p15
Official Symbol
vpr
Gene ID
UniProt ID
Synonyms
gag; Gag; polyprotein; Human Immunodeficiency virus 1; Nucleocapsid protein p7; p15; p6 gag; Pr55Gag; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; ADIS; HIV
Introduction
HIV1 p15(Gag) and its protease cleavage products, nucleocapsid protein p7 and p6, are believed to play a major role in viral infectivity and assembly during the early and late stages of retroviral life cycle. p15 is frequently recognized by HIV1-specific CD8+T cells in natural HIV1 infection and may be an important target for the design of future HIV1 vaccines.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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