pCDCAR1 CD19 h(t2B4)(CAR-MZ097)

The vector of anti-CD19 chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human CD19. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD19 antibody linked to t2B4 signaling domains. And the vector product was designed for the treatment of Leukemia and Neuroblastoma.


Details


Target
CD19
Target Species
Human
Targeting Cell Type
NK cell
Targeting Diseases
Leukemia and Neuroblastoma
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral
Receptor Construction
scFv-t2B4
Discription of Signaling Cassetes
2B4
CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.
Antibody Clone
FMC-63
Antibody Host
Mouse

Target


Gene Name
CD19 molecule
Official Symbol
CD19
Gene ID
Synonyms
CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; MDX-1342

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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