pCDCAR1 EGFRvIII h(DAP12)(CAR-MZ138)

The vector of anti-EGFRvIII chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human EGFRvIII. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFRvIII antibody linked to DAP12 signaling domains. And the vector product was designed for the treatment of Glioblastoma.


Details


Target
EGFRvIII
Target Species
Human
Targeting Cell Type
NK cell
Targeting Diseases
Glioblastoma
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral
Receptor Construction
scFv-DAP12
Discription of Signaling Cassetes
DAP12
DAP12 is a 12 kDa transmembrane protein recently recognized as a key signal transduction receptor element in Natural Killer (NK) cells. It is a disulfide-linked homodimer that non-covalently associates with several activating receptors expressed on NK cells.
Antibody Clone
MR1.1
Antibody Host
Human

Target


Gene Name
epidermal growth factor receptor
Official Symbol
EGFR
Gene ID
Synonyms
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; mAb806; LICR 806; ABT-806; ch806

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CarcinomaGliomaBlastomaOthers

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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