pCDCAR1 HCV/E2 h(ζ)(CAR-MZ179)

The vector of anti-HCV/E2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human HCV/E2. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-HCV/E2 antibody linked to CD3ζ signaling domains. And the vector product was designed for the treatment of Hepatitis C virus (HCV) infection.


Details


Target
HCV/E2
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Hepatitis C virus (HCV) infection
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Retroviral
Receptor Construction
scFv-CD3ζ
Discription of Signaling Cassetes
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
Antibody Clone
e137
Antibody Host
Human

Target


Gene Name
HCV/E2
Official Symbol
HCV/E2
Synonyms
HCV/E2

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-097-1828

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