pCDCAR1 HLA-A2-WT1Db126 h(BBFcγR1γ)(CAR-LC266)

The vector of anti-HLA-A2-WT1Db126 chimeric antigen receptor (CAR) is TCR-like CAR constructed for the engineering of T cells to target human HLA-A2-WT1Db126. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-HLA-A2-WT1Db126 antibody linked to CD28 signaling domain and FcγR1γ. And the vector product was designed for the treatment of breast carcinoma and colon cancer.


Details


Target
HLA-A2-WT1DB126
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Breast carcinoma, Colon cancer
Generation
Second
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Retroviral
Receptor Construction
scFv-CD28-FcγR1γ
Discription of Signaling Cassetes
CD28
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells (APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
Antibody Clone
F2
Antibody Host
Human

Target


Gene Name
HLA-A2-WT1Db126 complex
Official Symbol
HLA-A2-WT1Db126
Synonyms
HLA-A2-WT1Db126; HLA-A2-WT1Db126 complex

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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CONTACT US

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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