Anti-ABCD3 T cell receptor (LC13), pCDTCR1(TCR-C008Z)

The vector of anti-ABCD3 T cell receptor (TCR) is constructed for the engineering of T cell to target Human ABCD3. The T cells are genetically modified through transduction with a lentiviral vector expressing ABCD3-specific T cell receptor. And the vector product was designed for the treatment of Bile Acid Synthesis Defect, Congenital and Zellweger Syndrome.


Details


Target
ABCD3
Target Species
Human
Epitope
EEYLQAFTY
Format
Non-modified
HLA
HLA-B*4405
Targeting Diseases
Bile Acid Synthesis Defect, Congenital and Zellweger Syndrome
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
LC13
Antibody Host
Human

Target


Gene Name
ATP binding cassette subfamily D member 3
Official Symbol
ABCD3
Gene ID
UniProt ID
Synonyms
ABCD3; ZWS2; ABC43; CBAS5; PMP70; PXMP1; ATP binding cassette subfamily D member 3
Introduction
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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