Anti-INS T cell receptor (FS17), pCDTCR1(TCR-C106Z)
The vector of anti-INS T cell receptor (TCR) is constructed for the engineering of T cell to target Human INS. The T cells are genetically modified through transduction with a lentiviral vector expressing INS-specific T cell receptor. And the vector product was designed for the treatment of Type 1 diabetes.
Type 1 diabetes
IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10; INS; Insulin
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.