Anti-NS3-4A protein T cell receptor (DD31), pCDTCR1(TCR-C184Z)
The vector of anti-NS3-4A protein T cell receptor (TCR) is constructed for the engineering of T cell to target HCV NS3-4A protein. The T cells are genetically modified through transduction with a lentiviral vector expressing NS3-4A protein-specific T cell receptor. And the vector product was designed for the treatment of HCV infection.
NS3-4A protein; HCV
HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV has four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B). NS5A is a hydrophilic phosphoprotein which plays an important role in viral replication, modulation of cell signaling pathways and the interferon response. It is known to bind to endoplasmic reticulum anchored human VAP proteins.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.