Anti-NS3 T cell receptor (JK4), pCDTCR1(TCR-C182Z)

The vector of anti-NS3 T cell receptor (TCR) is constructed for the engineering of T cell to target DENV-4 NS3. The T cells are genetically modified through transduction with a lentiviral vector expressing NS3-specific T cell receptor. And the vector product was designed for the treatment of Dengue fever.


Details


Target
NS3
Target Species
DENV-4
Epitope
VIGLYGNGV
Format
Non-modified
HLA
HLA-DR15
Targeting Diseases
Dengue fever
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
JK4
Antibody Host
Human

Target


Gene Name
Nonstructural protein 3
Official Symbol
NS3
Synonyms
Nonstructural protein 3; NS3; p-70
Introduction
The DENV NS3 is a serine protease, as well as an RNA helicase and RTPase/NTPase. The protease domain consists of six β-strands arranged into two β-barrels formed by residues 1–180 of the protein. The catalytic triad (His-51, Asp-75 and Ser-135), is found between these two β-barrels, and activity is dependent on the presence of the NS2B cofactor. This cofactor wraps around the NS3 protease domain and becomes part of the active site. The remaining NS3 residues (180–618), form the three subdomains of the DENV helicase. A six-stranded parallel β-sheet surrounded by four α-helices make up subdomains I and II, and subdomain III is composed of 4 α-helices surrounded by three shorter α-helices and two antiparallel β-strands.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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