Anti-Rac-1 T cell receptor (T2), pCDTCR1(TCR-L215)

The vector of anti-Rac-1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human Rac-1. The T cells are genetically modified through transduction with a lentiviral vector expressing Rac-1-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
Rac-1
Target Species
Human
Epitope
FSGEHPTV
Format
Non-modified
HLA
HLA-A201
Targeting Diseases
Melanoma
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
T2
Antibody Host
Human

Target


Gene Name
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Official Symbol
RAC1
Gene ID
UniProt ID
Synonyms
MIG5; Rac-1; TC-25; p21-Rac1
Introduction
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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