Anti-TPI T cell receptor (E8), pCDTCR1(TCR-C252Z)

The vector of anti-TPI T cell receptor (TCR) is constructed for the engineering of T cell to target Human TPI. The T cells are genetically modified through transduction with a lentiviral vector expressing TPI-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.


Details


Target
TPI
Target Species
Human
Epitope
aa 23-37
Format
Non-modified
HLA
HLA-DR1
Targeting Diseases
Melanoma
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
E8
Antibody Host
Human

Target


Gene Name
triosephosphate isomerase 1
Official Symbol
TPI1
Gene ID
UniProt ID
Synonyms
TPI1; TIM; TPI; TPID; HEL-S-49
Introduction
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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