Anti-Env T cell receptor (RT-1), pCDTCR1(TCR-L348)

The vector of anti-Env T cell receptor (TCR) is constructed for the engineering of T cell to target HIV-l Env. The T cells are genetically modified through transduction with a lentiviral vector expressing Env-specific T cell receptor. And the vector product was designed for the treatment of AIDS.


Details


Target
Env
Target Species
HIV-l
Epitope
RIQRGPGRAFVTIGK
Format
Non-modified
HLA
H-2D
Targeting Diseases
AIDS
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
RT-1
Antibody Host
Mouse

Target


Gene Name
envelope glycoprotein
Official Symbol
Env
Synonyms
HIV-1 envelope glycoprotein (Env); Human immunodeficiency virus-1 envelope glycoprotein (Env); human immunodeficiency virus; HIV; Retroviridae
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, preejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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