Anti-FTO T cell receptor (2C), pCDTCR1(TCR-C009Z)

The vector of anti-FTO T cell receptor (TCR) is constructed for the engineering of T cell to target Human FTO. The T cells are genetically modified through transduction with a lentiviral vector expressing FTO-specific T cell receptor.


Details


Target
FTO
Target Species
Human
Epitope
LSPFPFDL
Format
Non-modified
HLA
H-2Ld
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
2C
Antibody Host
Mouse

Target


Gene Name
FTO, alpha-ketoglutarate dependent dioxygenase
Official Symbol
FTO
Gene ID
UniProt ID
Synonyms
FTO; GDFD; ALKBH9; BMIQ14; alpha-ketoglutarate dependent dioxygenase
Introduction
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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