Anti-NS5A T cell receptor (19), pCDTCR1(TCR-C185Z)

The vector of anti-NS5A T cell receptor (TCR) is constructed for the engineering of T cell to target HCV NS5A. The T cells are genetically modified through transduction with a lentiviral vector expressing NS5A-specific T cell receptor. And the vector product was designed for the treatment of HCV infection.


Details


Target
NS5A
Target Species
HCV
Epitope
VLTDFKTWL
Format
Codon optimized
HLA
HLA-A2
Targeting Diseases
HCV infection
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
19
Antibody Host
Mouse

Target


Gene Name
Nonstructural protein 5A
Official Symbol
NS5A
Synonyms
HCV NS5A; Hepatitis C virus Nonstructural protein 5A; Hepatitis C virus NS5A
Introduction
HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV has four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B). NS5A is a hydrophilic phosphoprotein which plays an important role in viral replication, modulation of cell signaling pathways and the interferon response. It is known to bind to endoplasmic reticulum anchored human VAP proteins.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


Blastoma

Online Inquiry

Name:
Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON