pCDCAR1 CD47 h(FcεRIγ), T(CAR-T-1-L344-G)

The vector of anti-CD47 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD47. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD47 antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of B-cell malignancies.


Details


Target
CD47
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
B-cell malignancies
Generation
First
Vector Name
pCDCAR1
Vector Length
8kb
Vector Type
Lentiviral vector
Receptor Construction
scFv-FcεRIγ
Discription of Signaling Cassetes
FcεRIγ
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
Antibody Clone
B6H12.2
Antibody Host
Mouse

Target


Gene Name
CD47 molecule
Official Symbol
CD47
Gene ID
Synonyms
CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv; B6H12.2

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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