pCDCAR1 ErbB2 h(b2cζ), NK(CAR-NK-2-M331-CZ)

The vector of anti-ErbB2 (HER2) chimeric antigen receptor(CAR) is constructed for the engineering of NK cell to target human ErbB2. The NK cell is genetically modified through transduction with a lentiviral vector expressing scFv of anti-ErbB2 antibody linked to b2c and CD3-zeta signaling domains. And the vector product was designed for the treatment of breast carcinomas, ovarian carcinoma .


Details


Target
ErbB2 (HER2)
Target Species
Human
Targeting Cell Type
NK cell
Targeting Diseases
Breast carcinomas; ovarian carcinoma
Generation
Second
Vector Name
pCDCAR1
Vector Length
8kb
Vector Type
Lentiviral vector
Receptor Construction
scFv-b2c-CD3ζ
Discription of Signaling Cassetes
b2c
The b2c protein belongs to high-sulphur keratin family which comprises at least three proteins, B2A, B2B and B2C. And b2c in chimeric antigen receptorsvcqn improve T-cell effector functions and enhance anti-tumor activity.
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
Antibody Clone
FRP5
Antibody Host
Rabbit

Target


Gene Name
erb-b2 receptor tyrosine kinase 2
Official Symbol
ErbB2
Gene ID
Synonyms
Human papillomavirus; HPV; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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