pCDCAR1 MICA h(4FcεRIγ), T(CAR-T-2-L407-4G)

The vector of anti-MICA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human MICA. The T cells are genetically modified through transduction with a lentiviral vector expressing NKG2D linked to a CD4 transmembrane domain and FcεRIγ signaling domains. And the vector product was designed for treating cancer and other proliferative disorders, as well as infectious diseases.


Details


Target
MICA
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Acute lymphoblastic leukemia (ALL)
Generation
Second
Vector Name
pCDCAR1
Vector Length
8kb
Vector Type
Lentiviral vector
Receptor Construction
scFv-CD4-FcεRIγ
Discription of Signaling Cassetes
CD4
Cluster of Differentiation 4 (CD4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). CD4 signaling in CAR ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation.
FcεRIγ
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
Antibody Host
Human

Target


Gene Name
MHC class I polypeptide-related sequence A
Official Symbol
MICA
Synonyms
MIC-A; HLA class I antigen; FLJ36918; FLJ60820; MGC111087; MGC21250; MHC class I chain related gene A protein; MHC class I chain related protein A; MHC class I chain related protein A HLA B HLA C; MHC class I polypeptide related sequence A; MHC class I polypeptide-related sequence A; MHC class I related protein; MIC A; micA; MICA_HUMAN;OTTHUMP00000029088; OTTHUMP00000044528; OTTHUMP00000165170; OTTHUMP00000165172; PERB11.1; Stress inducible class I homolog; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-048-3343

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