pCDCAR1 NY-ESO-1 h(b2cζ), T(CAR-T-2-M323-CZ)

The vector of anti-NY-ESO-1 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human NY-ESO-1. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-NY-ESO-1 antibody linked to b2c and CD3-zeta signaling domains. And the vector product was designed for the treatment of metastatic melanoma and synovial cell sarcoma.


Details


Target
NY-ESO-1
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Metastatic melanoma; synovial cell sarcoma
Generation
Second
Vector Name
pCDCAR1
Vector Length
8kb
Vector Type
Lentiviral vector
Receptor Construction
scFv-b2c-CD3ζ
Discription of Signaling Cassetes
b2c
The b2c protein belongs to high-sulphur keratin family which comprises at least three proteins, B2A, B2B and B2C. And b2c in chimeric antigen receptors improve T-cell effector functions and enhance anti-tumor activity.
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
Antibody Clone
ES121
Antibody Host
Mouse

Target


Gene Name
cancer/testis antigen 1B
Official Symbol
CTAG1B
Gene ID
Synonyms
CTAG1B; cancer/testis antigen 1B; CTAG; ESO1; CT6.1; CTAG1; LAGE-2; LAGE2B; NY-ESO-1; NY-ESO-1–positive tumors; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; ES121

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


Carcinoma

Online Inquiry

Name:
Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-048-3343
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON