pCDCAR1 PSCA h(FcεRIγ), T(CAR-T-1-L347-G)

The vector of anti-PSCA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human PSCA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-PSCA antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of pancreatic cancer.


Details


Target
PSCA
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Pancreatic cancer
Generation
First
Vector Name
pCDCAR1
Vector Length
8kb
Vector Type
Lentiviral vector
Receptor Construction
scFv-FcεRIγ
Discription of Signaling Cassetes
FcεRIγ
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.

Target


Gene Name
prostate stem cell antigen
Official Symbol
PSCA
Gene ID
Synonyms
PSCA; prostate stem cell antigen; PRO232; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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