CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-048-3343
Fax: 1-631-207-8356
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Receptor Ligand-based CAR Construction Service

As a novel and advanced technology service provider, Creative Biolabs provides CellRapeutics™ receptor ligand-based CAR construction service. Our expert team has developed a variety of CAR products including scFv-based and non scFv-based CAR (receptor ligand-based), which can be tailored to meet your scientific goals and needs.

Receptor Ligand-based CAR Construction Service

An diagram adapted from Shi et al., 2014.
Huan Shi, Meili Sun, Lin Liu and Zhehai Wang. Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects. Molecular Cancer 2014, 13:219.

The classical CAR is composed of a single-chain variable fragment (scFv), a hinge region, a transmembrane domain (TM) and an endodomain (or two). Besides the classical CAR, Creative Biolabs also offers a novel non scFv-based CAR which can recognize and bind tumor antigens such as HER3 and HER4. This physiological CAR consists of an antigen receptor and a CD3ζ intracellular signaling domain with/without a TM and a spacer region, which can also be engineered into immune cells to target its ligands expressed on tumor cells. This approach increases the ability of T cells to recognize tumor associated targets and eliminate cancer cells, which has already been applied in the field of adoptive immunotherapy.

With years of experience, Creative Biolabs has created a solid platform for CAR construction. Please be free to contact us.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

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