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B7-H6 also called natural killer cell cytotoxicity receptor 3 ligand 1 (NCR3LG1), is a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. Interaction of B7H6 with NKp30 results in natural killer (NK) cell activation and cytotoxicity. B7-H6 was not detected in normal human tissues but was selectively expressed on a variety of human tumor cell lines, including T and B lymphomas, melanomas, and carcinomas. Furthermore, B7-H6 expression on tumor cells triggered NKp30-specific NK cell cytotoxicity and cytokine secretion. Thus, B7-H6 functions as a tumor-induced self-molecule that alerts in-nate immunity to cellular transformation via its interaction with the activating receptor NKp30.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| XS-0822-YF727 | Anti-Human B7-H6 (XW-727) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-727 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF728 | Anti-Human B7-H6 (XW-728) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-728 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-1122-YF727 | Anti-B7-H6 KIR CAR (scFv-KIR2DS2-DAP12, XW-727), pCDCAR1 | Human | XW-727 | Mouse | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF728 | Anti-B7-H6 KIR CAR (scFv-KIR2DS2-DAP12, XW-728), pCDCAR1 | Human | XW-728 | Human | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF1647 | Anti-B7-H6 TCR-ABR (scFv-TCRα, XW-727) CAR Plasmid, pCDCAR1 | Human | XW-727 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF1648 | Anti-B7-H6 TCR-ABR (scFv-TCRα, XW-728) CAR Plasmid, pCDCAR1 | Human | XW-728 | Human | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2567 | Anti-B7-H6 TCR-ABR (scFv-TCRβ, XW-727) CAR Plasmid, pCDCAR1 | Human | XW-727 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF2568 | Anti-B7-H6 TCR-ABR (scFv-TCRβ, XW-728) CAR Plasmid, pCDCAR1 | Human | XW-728 | Human | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF3487 | Anti-B7-H6 TCR-ABR (scFv-CD3γ, XW-727) CAR Plasmid, pCDCAR1 | Human | XW-727 | Mouse | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF3488 | Anti-B7-H6 TCR-ABR (scFv-CD3γ, XW-728) CAR Plasmid, pCDCAR1 | Human | XW-728 | Human | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF4407 | Anti-B7-H6 TCR-ABR (scFv-CD3δ, XW-727) CAR Plasmid, pCDCAR1 | Human | XW-727 | Mouse | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF4408 | Anti-B7-H6 TCR-ABR (scFv-CD3δ, XW-728) CAR Plasmid, pCDCAR1 | Human | XW-728 | Human | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF5327 | Anti-B7-H6 TCR-ABR (scFv-CD3ε, XW-727) CAR Plasmid, pCDCAR1 | Human | XW-727 | Mouse | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF5328 | Anti-B7-H6 TCR-ABR (scFv-CD3ε, XW-728) CAR Plasmid, pCDCAR1 | Human | XW-728 | Human | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF6247 | Anti-B7-H6 (XW-727) h(CD28-CD3ζ) CAR, pAAV | Human | XW-727 | Mouse | scFv-CD28-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF6248 | Anti-B7-H6 (XW-728) h(CD28-CD3ζ) CAR, pAAV | Human | XW-728 | Human | scFv-CD28-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF7167 | Anti-B7-H6 (XW-727) h(41BB-CD3ζ) CAR, pAAV | Human | XW-727 | Mouse | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF7168 | Anti-B7-H6 (XW-728) h(41BB-CD3ζ) CAR, pAAV | Human | XW-728 | Human | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF8087 | Anti-B7-H6 (XW-727) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-727 | Mouse | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF8088 | Anti-B7-H6 (XW-728) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-728 | Human | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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