B7-H6

B7-H6 also called natural killer cell cytotoxicity receptor 3 ligand 1 (NCR3LG1), is a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. Interaction of B7H6 with NKp30 results in natural killer (NK) cell activation and cytotoxicity. B7-H6 was not detected in normal human tissues but was selectively expressed on a variety of human tumor cell lines, including T and B lymphomas, melanomas, and carcinomas. Furthermore, B7-H6 expression on tumor cells triggered NKp30-specific NK cell cytotoxicity and cytokine secretion. Thus, B7-H6 functions as a tumor-induced self-molecule that alerts in-nate immunity to cellular transformation via its interaction with the activating receptor NKp30.

Associated Disease
Anti-B7-H6 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC349 T cell Second 47.39 ~8kb Retroviral scFv-CD28-CD3ζ-T2A-CD19t Mouse Inquiry
CAR-MZ234 T cell First ~8kb Retroviral NKp30 receptor-CD3ζ Human Inquiry
CAR-MZ235 T cell First ~8kb Retroviral NKp30-CD28TM-CD3ζ Human Inquiry
CAR-MZ236 T cell First ~8kb Retroviral NKp30-CD8αTM-CD3ζ Human Inquiry
CAR-MZ237 T cell Second ~8kb Retroviral NKp30-CD28-CD3ζ Human Inquiry
CAR-T-1-L346-2 T cell First 47.39 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L346-G T cell First 47.39 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L346-Z T cell First 47.39 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L346-2G T cell Second 47.39 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L346-2Z T cell Second 47.39 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L346-4G T cell Second 47.39 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L346-4Z T cell Second 47.39 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L346-8Z T cell Second 47.39 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L346-BZ T cell Second 47.39 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L346-CZ T cell Second 47.39 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L346-2BZ T cell Third 47.39 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L346-2XZ T cell Third 47.39 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
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