BCMA

B Cell Maturation Antigen (BCMA), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17),is encoded by TNFRSF17 gene in human. It is a transmembrane signaling protein preferentially expressed on plasma cells. It is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). Its ligands including BAFF and A Proliferation Inducing Ligand (APRIL). BCMA is involved in JNK and NF-kB activation pathways that induce B-cell development and autoimmune responses. BCMA has been implicated in autoimmune disorders as well as B-lymphocyte malignancies, leukemia, lymphomas, and multiple myeloma.

Associated Disease
  • T cell lymphoma
  • Multiple myeloma
  • Acute myelomonocytic leukemia (AMML)
  • Acute monocytic leukemia
  • Follicular lymphoma
Anti-BCMA CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC002 T cell Second J6M0 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC041 T cell Second C12A3.2 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC042 T cell Second C11D5.3 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC043 T cell Second C11D5.3 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC044 T cell Second C11D5.3 ~8kb Lentiviral scFv-OX40-CD3ζ Mouse Inquiry
CAR-LC045 T cell Third C11D5.3 ~8kb Lentiviral scFv-41BB-OX40-CD3ζ Mouse Inquiry
CAR-LC135 T cell Second P5A2 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC136 T cell Second A02_Rd4 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC137 T cell Second P5C1 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC138 T cell Second C01_Rd4 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC139 T cell Second COMBO_Rd4 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC140 T cell Second L3PY/H2DY ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC141 T cell Second P6AP-V1 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC260 T cell Second C12A3.2 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC261 T cell Second BC50 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC262 T cell Second BC30 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC285 T cell Third ~8kb Retroviral dAPRIL-CD28-OX40-CD3ζ Human Inquiry
CAR-LC286 T cell Third ~8kb Retroviral dAPRIL-CD8STK-CD28-OX40-CD3ζ Human Inquiry
CAR-MZ014 T cell Second C13F12.1 ~8kb Lentiviral scFv-41BB-CD3ζ Humanized Inquiry
CAR-MZ122 T cell Second 11D5-3 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-1-L335-2 T cell First MM0108-3D44 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L335-G T cell First MM0108-3D44 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L335-Z T cell First MM0108-3D44 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L335-2G T cell Second MM0108-3D44 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L335-2Z T cell Second MM0108-3D44 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L335-4G T cell Second MM0108-3D44 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L335-4Z T cell Second MM0108-3D44 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L335-8Z T cell Second MM0108-3D44 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L335-BZ T cell Second MM0108-3D44 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L335-CZ T cell Second MM0108-3D44 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L335-2BZ T cell Third MM0108-3D44 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L335-2XZ T cell Third MM0108-3D44 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

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Australia
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