CD138

CD138,or more well know as syndecan-1,encoded by SDC1 gene in human, is a member of the transmembrane heparan sulfate proteoglycan family, acts as an extracellular matrix receptor and is involved in many cellular functions, including cell-cell adhesion and cell-matrix adhesion. Expression of syndecan-1 typically is observed on the surface of mature epithelial cells; however, stromal expression also might be seen in developing tissues. It is also found on distinct stages of differentiation of normal lymphoid cells (pre-B), mesenchymal cells during development and in mature plasma cells. In addition to plasma cells, CD138 reactivity also has been described for the plasmacytoid tumor cells of herpesvirusassociated effusion lymphomas and has been reported with variable frequency in immunoblastic diffuse large B cell lymphoma (DLBCL). It is also a specific antigen on multiple myeloma cells. Indatuximab ravtansine targets this protein.

Associated Disease
  • Multiple Myelomas
  • Haematological malignancies
  • Diffuse large B cell lymphoma (DLBCL)
Anti-CD138 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC170 T cell Second Indatuximab ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC384 T cell Third NI16 ~8kb Lentiviral scFv-CD28-41BB-CD27-CD3ζ/iCasp9 Mouse Inquiry
CAR-MZ104 T cell Second Indatuximab ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
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