CD19

CD19 (Cluster of Differentiation 19), also called B lymphocyte antigen CD19, is a protein that in human is encoded by CD19 gene.The human CD19 antigen is a 95 kd transmembrane glycoprotein. It is found on the surface of B cell, function as B cell co-receptor that assemble with B cell antigen receptor in order to decrease the shreshold for antigen receptor dependent stimulation. CD19 usually expressed on follicular dendritic cells and B cells. As a hallmark of B cell, CD19 have highly conserved expression on most B cell tumors, though its not strong evidence show if CD19 contributes to B cell carcinogenesis directly. It is expressed in most acute lymphoblastic leukemias (ALL), chronic lymphocytic leukemias (CLL) and B cell lymphomas. In fact, the majority of B cell malignancies express CD19 at normal to high levels (80% of ALL, 88% of B cell lymphomas and 100% of B cell leukemias). For these reason, CD19 also a potential target for lymphoma therapy. Sevral monoclonal antibody and other antibody based immune therapy such as CAR-T technique are target at CD19. It is forseeable that CD19 mAb and molecularly engineered chimeric antigen receptor will be widely studied for therapies of lymphoma, leukemia and autoimmune disorders.

Associated Disease
Anti-CD19 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC004 T cell Second Denintuzumab ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC009 T cell Second 47G4 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC010 T cell Second 47G4 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC011 T cell Second 47G4 ~8kb Lentiviral scFv-CD27-CD3ζ Human Inquiry
CAR-LC012 T cell Third 47G4 ~8kb Lentiviral scFv-CD28-CD27-CD3ζ Human Inquiry
CAR-LC013 T cell Third 47G4 ~8kb Lentiviral scFv-41BB-CD27-CD3ζ Human Inquiry
CAR-LC014 T cell Third 47G4 ~8kb Lentiviral scFv-CD28-CD27-FcεRIγ Human Inquiry
CAR-LC015 T cell Second 47G4 ~8kb Lentiviral scFv-CD28-FcεRIγ Human Inquiry
CAR-LC016 T cell Third FMC63 ~8kb Lentiviral scFv-CD28-CD27-FcεRIγ Mouse Inquiry
CAR-LC142 T cell Second 104875 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC143 T cell Second 104876 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC144 T cell Second 104877 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC145 T cell Second 104878 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC146 T cell Second 104879 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC147 T cell Second 104880 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC148 T cell Second 104881 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC149 T cell Second 104882 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC150 T cell Second 105974 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC151 T cell Second 105975 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC152 T cell Second 105976 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC153 T cell Second 105977 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC154 T cell Second CTL019 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC163 T cell Second h119a ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC184 T cell First Coltuximab ~8kb Retroviral scFv-CD3ζ Human Inquiry
CAR-LC185 T cell Second Denintuzumab ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC186 T cell Second Coltuximab ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC193 T cell Second SJ25C1 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC225 T cell Second ~8kb Retroviral scFv-CD2-CD3ζ Mouse Inquiry
CAR-LC229 T cell Second S1 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC230 T cell Second S1 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC231 T cell Third S1 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC232 T cell Second S2 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC233 T cell Second S2 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC234 T cell Third S2 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC254 T cell Second ~8kb Lentiviral VNAR-41BB-CD3ζ Cartilaginous fish Inquiry
CAR-LC273 T cell First Denintuzumab ~8kb Retroviral scFv-RXR/EcR-CD3ζ Human Inquiry
CAR-LC274 T cell Third Denintuzumab ~8kb Retroviral scFv-FKBP12/FRB-CD28-OX40-CD3ζ Human Inquiry
CAR-LC277 T cell Second Denintuzumab ~8kb Lentiviral scFv-FKBP12 (DmrA)/FRB (DmrC)-41BB-CD3ζ Human Inquiry
CAR-LC278 T cell Second FMC63 ~8kb Lentiviral Fab-K4/E4-41BB-CD3ζ Mouse Inquiry
CAR-LC279 T cell Second FMC63 ~8kb Lentiviral Fab-E4/K4-41BB-CD3ζ Mouse Inquiry
CAR-LC294 T cell Third 4G7 ~8kb Lentiviral FcRα-scFv-CD8/FcRβ/FcRγ-ΔITAM-41BB-CD3ζ Mouse Inquiry
CAR-LC295 T cell Third 4G7 ~8kb Lentiviral FcRα-scFv-CD8/FcRβ-ΔITAM-41BB/FcRγ-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC296 T cell Third 4G7 ~8kb Lentiviral FcRα-scFv-CD8/FcRβ-ΔITAM-41BB-CD3ζ/FcRγ Mouse Inquiry
CAR-LC297 T cell Third 4G7 ~8kb Lentiviral FcRα-scFv-CD8/FcRβ-41BB/FcRγ-CD3ζ Mouse Inquiry
CAR-LC298 T cell Second 4G7 ~8kb Lentiviral FcRα-scFv-CD8-41BB/FcRβ/FcRγ Mouse Inquiry
CAR-LC299 T cell Third 4G7 ~8kb Lentiviral FcRα-scFv-CD8-41BB/FcRβ-ΔITAM-CD3ζ/FcRγ Mouse Inquiry
CAR-LC300 T cell Third 4G7 ~8kb Lentiviral FcRα-scFv-CD8-41BB/FcRβ/FcRγ-CD3ζ Mouse Inquiry
CAR-LC301 T cell Third 4G7 ~8kb Lentiviral FcRα-scFv-CD8-CD28/FcRβ-ΔITAM-41BB/FcRγ-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC348 T cell Second FMC63 ~8kb Lentiviral scFv-Strep Tag-41BB-CD3ζ Mouse Inquiry
CAR-LC350 T cell Second Blinatumomab ~8kb Lentiviral scFv-CD28-CD3ζ-EGFRt Mouse Inquiry
CAR-LC353 T cell Second Denintuzumab ~8kb Lentiviral scFv-41BB-CD3ζ/Her2t Human Inquiry
CAR-LC355 T cell Second FMC63 ~8kb Lentiviral FMC63VL-m971VH-m971VL-FMC63VH-41BB-CD3ζ Mouse Inquiry
CAR-LC356 T cell Second FMC63 ~8kb Lentiviral m971VH-m971VL-FMC63VL-FMC63VH-41BB-CD3ζ Mouse Inquiry
CAR-LC357 T cell Second Blinatumomab ~8kb Retroviral scFv (CD19)-scFv (HER2)-CD28-CD3ζ Mouse Inquiry
CAR-LC358 T cell Second Blinatumomab ~8kb Lentiviral scFv (CD19)-scFv (HER2)-41BB-CD3ζ Mouse Inquiry
CAR-LC359 T cell Second Blinatumomab ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC369 T cell Second Inebilizumab ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC381 T cell Second Denintuzumab ~8kb Retroviral iCasp9-2A-scFv-CD28-CD3ζ-2A-IL-15 Human Inquiry
CAR-LC382 T cell Second FMC63 ~8kb Nonviral CD20-scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC383 T cell Second Blinatumomab ~8kb Nonviral scFv-CD20-41BB-CD3ζ Mouse Inquiry
CAR-MZ001 T cell Second ~8kb Lentiviral scFv-CTLA4-CD3ζ Human  Inquiry
CAR-MZ020 T cell Second 1D3 ~8kb Retroviral scFv-CD28-CD3ζ Mice Inquiry
CAR-MZ048 T cell First Denintuzumab ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-MZ052 T cell Third ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-MZ095 NK cell First FMC-63 ~8kb Lentiviral scFv-2B4 Mouse Inquiry
CAR-MZ096 NK cell Second FMC-63 ~8kb Lentiviral scFv-2B4-CD3ζ Mouse Inquiry
CAR-MZ097 NK cell First FMC-63 ~8kb Lentiviral scFv-t2B4 Mouse Inquiry
CAR-MZ098 NK cell Second FMC-63 ~8kb Lentiviral scFv-t2B4-CD3ζ Mouse Inquiry
CAR-MZ125 T cell First SJ25C1 ~8kb Retroviral scFv-CD3ζ Mouse Inquiry
CAR-MZ127 T cell Second SJ25C1 ~8kb Retroviral scFv-DAP10-CD3ζ Mouse Inquiry
CAR-MZ128 T cell Second SJ25C1 ~8kb Retroviral scFv-CD3ζ-DAP10 Mouse Inquiry
CAR-MZ129 T cell Second SJ25C1 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-MZ130 T cell Second SJ25C1 ~8kb Retroviral scFv-OX40-CD3ζ Mouse Inquiry
CAR-MZ131 T cell Second ~8kb Lentiviral scFv-CD3ζ-41BB Humanized Inquiry
CAR-MZ244 T cell First ~8kb Retroviral CD19 scFv-HER2 scFv-CD3ζ Inquiry
CAR-MZ246 T cell Second ~8kb Retroviral CD19 scFv-HER2 scFv-41BB-CD3ζ Inquiry
CAR-MZ247 T cell Third ~8kb Retroviral CD19 scFv-HER2 scFv-CD28-41BB-CD3ζ Inquiry
CAR-NK-1-M328-2 NK cell First FMC63 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-NK-1-M328-G NK cell First FMC63 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-NK-1-M328-Z NK cell First FMC63 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-NK-2-M328-2Z NK cell Second FMC63 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-NK-2-M328-4G NK cell Second FMC63 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-NK-2-M328-4Z NK cell Second FMC63 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-NK-2-M328-8Z NK cell Second FMC63 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-NK-2-M328-BG NK cell Second FMC63 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-NK-2-M328-BZ NK cell Second FMC63 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-NK-2-M328-CZ NK cell Second FMC63 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-NK-3-M328-2BZ NK cell Third FMC63 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-NK-3-M328-2XZ NK cell Third FMC63 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CAR-T-1-L332-2 T cell First FMC63 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L332-G T cell First FMC63 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L332-Z T cell First FMC63 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L332-2G T cell Second FMC63 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L332-2Z T cell Second FMC63 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L332-4G T cell Second FMC63 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L332-4Z T cell Second FMC63 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L332-8Z T cell Second FMC63 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L332-BZ T cell Second FMC63 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L332-CZ T cell Second FMC63 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L332-2BZ T cell Third FMC63 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L332-2XZ T cell Third FMC63 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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