CD22

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. Recent studies reveal CD22 to be a functionally significant receptor during these processes. CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 is a member of the Ig superfamily that serves as an adhesion. CD22 is another member of the B-cell antigen family with a tissue distribution that is similar to CD19. A Siglec-family lectin, CD22 consists of 7 extracellular IgG-like domains and is expressed on the B-cell surface starting at the pre-B cell stage, persists on mature B cells, and is lost on plasma cells, reviewed by Nitschke. CD22 has been validated as a successful target for B-cell leukemias and lymphomas using an immunotoxin approach.

Anti-CD22 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC061 T cell Second HA22 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC062 T cell Third HA22 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC063 T cell Second HA22 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC064 T cell Second BL22 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC065 T cell Third BL22 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC157 T cell Second m971 ~8kb Retroviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC158 T cell Second m971 ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC159 T cell Third m971 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-T-1-M308-2 T cell First FMC63 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-M308-G T cell First FMC63 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-M308-Z T cell First FMC63 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-M308-2G T cell Second FMC63 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-M308-2Z T cell Second FMC63 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-M308-4G T cell Second FMC63 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-M308-4Z T cell Second FMC63 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-M308-8Z T cell Second FMC63 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-M308-BZ T cell Second FMC63 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-M308-CZ T cell Second FMC63 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-M308-2BZ T cell Third FMC63 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-M308-2XZ T cell Third FMC63 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
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