CD4

CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans, the CD4 protein is encoded by the CD4 gene. CD4 is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell. Using its intracellular domain, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, the tyrosine kinase Lck, which is essential for activating many molecular components of the signaling cascade of an activated T cell. CD4 continues to be expressed in most neoplasms derived from T helper cells. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma.

Associated Disease
  • Non-Hodgkin's lymphomas
  • Others
Anti-CD4 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC250 T cell Third Hu5A8 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
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