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CD4 ligands

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The CD4 surface receptor is mainly expressed on distinct populations of thymocytes and mature T-lymphocytes, but also at lower levels on macrophages, monocytes, and dendritic cells. CD4 is an integral membrane glycoprotein of approximately 58 kDa that contains four extracellular domains showing sequence and structural homologies with members of the immunoglobulin superfamily. The function of CD4 in the antigen presentation process is to contact nonpolymorphic regions of the MHC-II molecules expressed at the surface of APC. CD4 acts as an adhesion molecule that stabilizes the interaction between the TCR and MHC-II molecules loaded with antigenic peptides, but it also participates in signal-transduction pathways. CD4 could be a receptor for the lymphocyte chemotactic factor IL-16 and the secreted gp17 glycoprotein. In addition to its physiological functions, CD4 serves as the primary surface receptor for the HIV. Binding of the viral envelope glycoprotein gp120 to CD4 mediates attachment of the HIV particle, which then enters the cell through subsequent interactions with other non-CD4 cellular receptors.

Associated Disease
  • CD4-expressing tumors
  • HIV infection
  • Others
  • CAR Vector Products

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-MZ243 Anti-CD4 ligands, CD4 h(CD28-CD3ζ) CAR, pCDCAR1 Human Mouse CD4-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ248 Anti-CD4 ligands (10)×gp120 scFv h(CD28-CD3ζ) Bispecific CAR, pCDCAR1 Human Mouse CD4-10-gp120 scFv-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ249 Anti-CD4 ligands (35)×gp120 scFv h(CD28-CD3ζ) Bispecific CAR, pCDCAR1 Human Mouse CD4-35-gp120 scFv-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
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