The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11.CD44 is expressed in a large number of mammalian cell types. CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. it is responsible for mediating communication and adhesion between adjacent cells and between cells and the extracellular matrix (ECM). In addition to its role in cellular adhesion, CD44 can direct intracellular signaling for growth and motility, and thus it is involved in many types of cancers, including breast, lung, prostate, ovarian, cervical, and colorectal cancers and neuroblastoma.
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