CD47

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 is a transmembrane glycoprotein expressed on all cells in the body and particularly overexpressed on cancer cells and cancer stem cells of both hematologic and solid malignancies. In the immune system, CD47 acts as a "don't eat me" signal, inhibiting phagocytosis by macrophages by interaction with signal regulatory protein α (SIRPα). In cancer, CD47 promotes tumor invasion and metastasis.

Associated Disease
Anti-CD47 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC364 T cell Third 5F9 ~8kb Lentiviral scFv (CD47)-CD28-41BB-CD3ζ/scFv (TAZ)-TET2 Mouse Inquiry
CAR-T-1-L344-2 T cell First B6H12.2 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L344-G T cell First B6H12.2 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L344-Z T cell First B6H12.2 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L344-2G T cell Second B6H12.2 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L344-2Z T cell Second B6H12.2 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L344-4G T cell Second B6H12.2 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L344-4Z T cell Second B6H12.2 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L344-8Z T cell Second B6H12.2 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L344-BZ T cell Second B6H12.2 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L344-CZ T cell Second B6H12.2 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L344-2BZ T cell Third B6H12.2 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L344-2XZ T cell Third B6H12.2 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CONTACT US

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Tel: 1-631-871-5806
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Email:

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Tel: 44-207-097-1828

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