DOTA

DOTA, with a full name of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, is an organic compound. Its not a cancer cell surface molecule biomarker, but usually used as a complexing agent, especially for lanthanide ions. Its complexes have medical applications as contrast agents and cancer treatments.DOTA can be conjugated to monoclonal antibodies by attachment of one of the four carboxyl groups as an amide. The remaining three carboxylate anions are available for binding to the yttrium ion. The modified antibody accumulates in the tumour cells, concentrating the effects of the radioactivity of 90Y.

Associated Disease
  • Various cancer cells stained with DOTA-labeled antibodies
  • Others
Anti-DOTA CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC059 T cell Second ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON