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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
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DOTA, with a full name of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, is an organic compound. Its not a cancer cell surface molecule biomarker, but usually used as a complexing agent, especially for lanthanide ions. Its complexes have medical applications as contrast agents and cancer treatments.DOTA can be conjugated to monoclonal antibodies by attachment of one of the four carboxyl groups as an amide. The remaining three carboxylate anions are available for binding to the yttrium ion. The modified antibody accumulates in the tumour cells, concentrating the effects of the radioactivity of 90Y.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC059 | Anti-DOTA h(41BB-CD3ζ) CAR, pCDCAR1 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||||
| CAR-ZP2750 | Anti-DOTA (XR183) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | XR183 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP2751 | Anti-DOTA (XR183) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | XR183 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP179 | Anti-DOTA (LG1) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | LG1 | Mouse | scFv-41BB-CD32ζ | Lentiviral vector | T cell | ||
| XS-1022-ZP180 | Anti-DOTA (LG1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | LG1 | Mouse | scFv-CD28-CD32ζ | Lentiviral vector | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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