EBNA3C is encoded by Epstein-Barr virus (EBV), which is one of the latent proteins. As a potent transcriptional coregulator that interacts with numerous cellular proteins, EBNA3C is essentially involved in regulating multiple important cellular pathways, including cell cycle and apoptosism. Therefore, EBNA3C is playing a critical role in EBV-induced growth transformation of primary B lymphocytes. EBNA3C is related to Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC), and AIDS-associated lymphomas.
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