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The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers, glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-ZP8476 | A uniCAR [Anti-FITC CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8493 | A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8494 | A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Panitumumab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-MV-01LX039 | Anti-EGFR (EGFR-scFv) h(CD28-CD3ζ) CAR, pMMLV | Human | EGFR-scFv | Human | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| XS-0822-YF315 | Anti-Human EGFR (XW-315) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-315 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF316 | Anti-Human EGFR (XW-316) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-316 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF317 | Anti-Human EGFR (XW-317) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-317 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF318 | Anti-Human EGFR (XW-318) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-318 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF319 | Anti-Human EGFR (XW-319) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-319 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF320 | Anti-Human EGFR (XW-320) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-320 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF321 | Anti-Human EGFR (XW-321) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-321 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF322 | Anti-Mouse EGFR (XW-322) m(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-322 | Rabbit | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF323 | Anti-Mouse EGFR (XW-323) m(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-323 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF324 | Anti-Mouse EGFR (XW-324) m(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-324 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF325 | Anti-Mouse EGFR (XW-325) m(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-325 | Rabbit | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF326 | Anti-Human EGFR (XW-326) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-326 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF327 | Anti-Human EGFR (XW-327) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-327 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1235 | Anti-Human EGFR (XW-315) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-315 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1236 | Anti-Human EGFR (XW-316) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-316 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2155 | Anti-Human EGFR (XW-315) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-315 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2156 | Anti-Human EGFR (XW-316) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-316 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2157 | Anti-Human EGFR (XW-317) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-317 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2158 | Anti-Human EGFR (XW-318) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-318 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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