G250 epitope

G250 refers to a monoclonal antibody (mAb) that was raised more than 10 years ago by immunization of mice with human renal cell carcinoma(RCC) homogenates. The RCC-associated transmembrane protein designated G250 has since been proven to be identical to tumor-associated protein MN or CA IX. The normal function of CA IX is to catalyze the reversible conversion of carbon dioxide and water to carbonic acid, playing a role in the intra- and extracellular pH regulation of cells. It has been implicated as an intrinsic marker of hypoxia and as a prognostic marker for several types of human tumors. CA IX has also been shown to be a useful prognostic biomarker for RCC.

Associated Disease
Anti-G250 epitope CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC371 T cell ~8kb Lentiviral iRGD-scFv-CD28-41BB-CD3ζ Human Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON