Glypican-3 (GPC3)

Glypican 3 (GPC3), also known as DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1, is encoded by the GPC3 gene that belongs to the member of the glypican family. This protein is highly expressed in embryonal tissues such as the developing intestine and the mesoderm-derived tissue, and its expression is downregulated in most adult tissue. GPC3 is able not only to bind more than one growth factor, but also to functionally affect the signaling of different growth factors. GPC3 is related to hepatocellular carcinoma, Wilm's tumor, colorectal malignancie, neuroblastoma, medullary cell carcinoma, mesothelioma, ovarian cancer and breast cancer.

Associated Disease
Anti-Glypican-3 (GPC3) CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC046 T cell First GC33 ~8kb Retroviral scFv-CD3ζ Mouse Inquiry
CAR-LC047 T cell Second GC33 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC048 T cell Second GC33 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC049 T cell Third GC33 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC090 T cell First ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-LC091 T cell Second ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC092 T cell Second ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC093 T cell Third ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC178 T cell First 3E11 ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-LC179 T cell Second 3E11 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC180 T cell Third 3E11 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC363 T cell Third YP7 ~8kb Lentiviral scFv (GPC3)-CD3ζ/scFv (ASGPR1)-CD28-41BB Mouse Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON