GPC3

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Associated Disease
  • Hepatocellular carcinoma
Anti-GPC3 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-L342-2 T cell First 9C2 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L342-G T cell First 9C2 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L342-Z T cell First 9C2 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L342-2G T cell Second 9C2 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L342-2Z T cell Second 9C2 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L342-4G T cell Second 9C2 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L342-4Z T cell Second 9C2 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L342-8Z T cell Second 9C2 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L342-BZ T cell Second 9C2 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L342-CZ T cell Second 9C2 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L342-2BZ T cell Third 9C2 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L342-2XZ T cell Third 9C2 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
Anti-GPC3 TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C088Z Human P1-1 Murinized ~8kb Lentiviral FIDKKVLKV Codon optimized HLA-A2 Inquiry
TCR-C089Z Human P2-1 Murinized ~8kb Lentiviral TIHDSIQYV Codon optimized HLA-A2 Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

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Australia
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