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Human leukocyte antigens A2 (HLA-A2), also known as HLA-A*02, is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In human melanoma, the expression of HLA-A2 antigen in human melanoma expression is related to tumor cell recognition by autologous T Iymphocytes. Furthermore, HLA-A2 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. HLA-A2 is linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-MZ109 | Anti-HLA-A2 (BB7.2) h(CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-MZ110 | Anti-HLA-A2 (BB7.2) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-MZ111 | Anti-HLA-A2 (BB7.2) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-M0176-YC | Anti-HLA-A2 (BB7.2) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-M0587-YC | Anti-HLA-A2 (BB7.2) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 | Human | BB7.2 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0622-ZP3303 | Anti-HLA-A2 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3475 | Anti-HLA-A2 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0822-YF512 | Anti-Human HLA-A2 (XW-512) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-512 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF513 | Anti-Human HLA-A2 (XW-513) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-513 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1432 | Anti-Human HLA-A2 (XW-512) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-512 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1433 | Anti-Human HLA-A2 (XW-513) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-513 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2352 | Anti-Human HLA-A2 (XW-512) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-512 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2353 | Anti-Human HLA-A2 (XW-513) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-513 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-1122-YF1432 | Anti-HLA-A2 TCR-ABR (scFv-TCRα, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF1433 | Anti-HLA-A2 TCR-ABR (scFv-TCRα, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2352 | Anti-HLA-A2 TCR-ABR (scFv-TCRβ, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF2353 | Anti-HLA-A2 TCR-ABR (scFv-TCRβ, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF3272 | Anti-HLA-A2 TCR-ABR (scFv-CD3γ, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF3273 | Anti-HLA-A2 TCR-ABR (scFv-CD3γ, XW-513) CAR Plasmid, pCDCAR1 | Human | XW-513 | Mouse | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF4192 | Anti-HLA-A2 TCR-ABR (scFv-CD3δ, XW-512) CAR Plasmid, pCDCAR1 | Human | XW-512 | Mouse | scFv-CD3δ | Lentiviral vector | T Cell |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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