INS

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Associated Disease
  • Type 1 diabetes
Anti-INS TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C105Z Human FS18 Human ~8kb Lentiviral GSLQPLALEGSLQKRG Non-modified HLA-DR4 Inquiry
TCR-C106Z Human FS17 Human ~8kb Lentiviral GSLQPLALEGSLQKRG Non-modified HLA-DR4 Inquiry
TCR-C107Z Human G9C8 Mouse ~8kb Lentiviral LYLVCGERV Non-modified H-2Kd Inquiry
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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-097-1828

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