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LeY

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LeY represents lewis antigen. The Lewis antigen system is a human blood group system based upon genes on chromosome 19 p13.3 (FUT3 or Lewis gene) and 19q13.3, (FUT2 or secretor gene). Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional. There are two main types of Lewis antigens, Lewis a (Le-a) and Lewis b (Le-b). There are three common phenotypes: Le(a+b-), Le(a-b+), and Le(a-b-). They are red cell antigens which are not produced by the erythrocyte itself. Instead, Lewis antigens are components of exocrine epithelial secretions, and are subsequently adsorbed onto the surface of the erythrocyte. The Le(b) and H antigens are receptors for the bacteria Helicobacter pylori, a gram-negative bacterium that can cause gastritis and has been implicated in peptic ulcer disease, gastric adenocarcinoma, mucosa-associated lymphoma (or mucosal associated lymphatic tissue lymphoma- MALToma) and idiopathic thrombocytopenic purpura (ITP).

Associated Disease
  • LeY-expressing acute myeloid leukemia (AML)
  • Acute myeloid leukemia (AML)
  • CAR Vector Products

  • AbTCR Vector Products

  • CAR Cell Products

  • CAR Viral Particles

  • TriCAR Vector Products

  • CAR Animal Cells

  • CAR mRNA

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-0822-YF2453 Anti-Human LeY (XW-613) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-613 Human scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2454 Anti-Human LeY (XW-614) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-614 Human scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2455 Anti-Human LeY (XW-615) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-615 Human scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2456 Anti-Human LeY (XW-616) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-616 Mouse scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2457 Anti-Human LeY (XW-617) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-617 Human scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2458 Anti-Human LeY (XW-618) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-618 Human scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2459 Anti-Human LeY (XW-619) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-619 Human scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2460 Anti-Mouse LeY (XW-620) m(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Mouse XW-620 Rat scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF8429 TS-Fluc Anti-Human LeY scFv (XW-613) CD28-CD3ζ CAR, pCDCAR1 Human XW-613 Human 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF8430 TS-Fluc Anti-Human LeY scFv (XW-614) CD28-CD3ζ CAR, pCDCAR1 Human XW-614 Human 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF8431 TS-Fluc Anti-Human LeY scFv (XW-615) CD28-CD3ζ CAR, pCDCAR1 Human XW-615 Human 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF8432 TS-Fluc Anti-Human LeY scFv (XW-616) CD28-CD3ζ CAR, pCDCAR1 Human XW-616 Mouse 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF8433 TS-Fluc Anti-Human LeY scFv (XW-617) CD28-CD3ζ CAR, pCDCAR1 Human XW-617 Human 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF8434 TS-Fluc Anti-Human LeY scFv (XW-618) CD28-CD3ζ CAR, pCDCAR1 Human XW-618 Human 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF8435 TS-Fluc Anti-Human LeY scFv (XW-619) CD28-CD3ζ CAR, pCDCAR1 Human XW-619 Human 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF8436 TS-Fluc Anti-Mouse LeY scFv (XW-620) CD28-CD3ζ CAR, pCDCAR1 Mouse XW-620 Rat 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF9247 TS-Fluc Anti-Human LeY scFv (XW-613) CD28-41BB-CD3ζ CAR, pCDCAR1 Human XW-613 Human 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF9248 TS-Fluc Anti-Human LeY scFv (XW-614) CD28-41BB-CD3ζ CAR, pCDCAR1 Human XW-614 Human 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF9249 TS-Fluc Anti-Human LeY scFv (XW-615) CD28-41BB-CD3ζ CAR, pCDCAR1 Human XW-615 Human 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
XS-0822-YF9250 TS-Fluc Anti-Human LeY scFv (XW-616) CD28-41BB-CD3ζ CAR, pCDCAR1 Human XW-616 Mouse 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
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