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Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA or "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines. The self-antigen Melan-A/MART-1 is frequently involved in T-cell responses against malignant melanoma. The use of fluorescent tetramers incorporating the immunodominant Melan-A/MART-1 peptide has provided new insights into HLA-A2-restricted T-cell responses against this antigen in cancer patients and in healthy individuals. Direct evidence has been provided that a large Melan-A/MART-1-specific CD8 T-cell pool is generated during thymic selection. Although several other examples of naive self-peptide-specific T-cell repertoires are known, this is the only one directly accessible to analysis in healthy individuals.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-1-M310-2 | Anti-MART-1(DMF5) scFv h(CD28) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28 | Lentiviral | T cell | ||
| CAR-T-1-M310-G | Anti-MART-1(DMF5) scFv h(FcεRIγ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-1-M310-Z | Anti-MART-1(DMF5) scFv h(CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-2G | Anti-MART-1(DMF5) scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-M310-2Z | Anti-MART-1(DMF5) scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-4G | Anti-MART-1(DMF5) scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD4-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-M310-8Z | Anti-MART-1(DMF5) scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD8-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-BZ | Anti-MART-1(DMF5) scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-CZ | Anti-MART-1(DMF5) scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-b2c-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-M310-2BZ | Anti-MART-1(DMF5) scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-M310-2XZ | Anti-MART-1(DMF5) scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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