MBP

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Associated Disease
  • Multiple sclerosis (MS)
Anti-MBP TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C146Z Human Hy.2E11 Murinized ~8kb Lentiviral ENPVVHFFKNIVTPR Murinized HLA-DRB1*1501 Inquiry
TCR-C147Z Human 172.10 Mouse ~8kb Lentiviral SRGGASQYRPSQ Non-modified I-Au Inquiry
TCR-C148Z Human Ob.1A12 Human ~8kb Lentiviral ENPVVHFFKNIVTPR Non-modified HLA-DR2 Inquiry
TCR-C149Z Human 3A6 Human ~8kb Lentiviral VHFFKNIVTPRTP Non-modified HLA-DR2a Inquiry
TCR-C150Z Human 1.D9.B2 Mouse ~8kb Lentiviral GGRASDYKSAH Single-chain I-Au Inquiry
TCR-C151Z Human 1.D9.B2 Mouse ~8kb Lentiviral KGFKGAYDAQG Single-chain I-Au Inquiry
TCR-C152Z Human OB Human ~8kb Lentiviral aa 84-102 Non-modified HLA-DR2b Inquiry
TCR-C153Z Human MS2-3C8 Human ~8kb Lentiviral aa 111-129 Non-modified HLA-DR4 Inquiry
TCR-C154Z Human Hy.1B11 Human ~8kb Lentiviral ENPVVHFFKNIVTPR Non-modified HLA-DQ1 Inquiry
TCR-C155Z Human Hy.1F9 Human ~8kb Lentiviral aa 84-102 Non-modified HLA-DR2 Inquiry
TCR-C156Z Human Murinized ~8kb Lentiviral KIFKLGGRDSRSGSPMARR Murinized HLA-DR13 Inquiry
TCR-L069Z Human Human 8kb Lentiviral MBP[89-101] Non-modified HLA-A2 Inquiry
TCR-L070 Human Human 6714-6688bp retroviral vector MBP[89-101] Non-modified TCR HLA-A2 Inquiry
TCR-L269 Human Hy.2H9 Human ~8kb Lentiviral aa 85-99 Non-modified HLA-DR2 Inquiry
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