MUC1

Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. It is overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor-associated MUC1 differs from the MUC1 expressed in normal cells with regard to its biochemical features, cellular distribution, and function. In cancer cells, MUC1 participates in intracellular signal transduction pathways and regulates the expression of its target genes at both the transcriptional and post-transcriptional levels.

Associated Disease
  • MUC1-expressing tumors, viral infection
  • Others
Anti-MUC1 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC251 T cell Third Pemtumomab ~8kb Nonviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC361 T cell Second Pemtumomab ~8kb Nonviral scFv (MUC1)-CD3ζ/Herin-CD28-41BB Mouse Inquiry
CAR-T-1-M303-2 T cell First SM3; HMFG2 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-M303-G T cell First SM3; HMFG2 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-M303-Z T cell First SM3; HMFG2 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-1-M553-2 T cell First 8kb Lentiviral VHH-CD28 camelid Inquiry
CAR-T-1-M553-G T cell First 8kb Lentiviral VHH-FcεRIγ camelid Inquiry
CAR-T-1-M553-Z T cell First 8kb Lentiviral VHH-CD3ζ camelid Inquiry
CAR-T-2-M303-2G T cell Second SM3; HMFG2 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-M303-2Z T cell Second SM3; HMFG2 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-M303-4G T cell Second SM3; HMFG2 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-M303-4Z T cell Second SM3; HMFG2 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-M303-8Z T cell Second SM3; HMFG2 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-M303-BZ T cell Second SM3; HMFG2 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-M303-CZ T cell Second SM3; HMFG2 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-2-M553-2G T cell Second 8kb Lentiviral VHH-CD28-FcεRIγ camelid Inquiry
CAR-T-2-M553-2Z T cell Second 8kb Lentiviral VHH-CD28-CD3ζ camelid Inquiry
CAR-T-2-M553-4G T cell Second 8kb Lentiviral VHH-CD4-FcεRIγ camelid Inquiry
CAR-T-2-M553-4Z T cell Second 8kb Lentiviral VHH-CD4-CD3ζ camelid Inquiry
CAR-T-2-M553-8Z T cell Second 8kb Lentiviral VHH-CD8-CD3ζ camelid Inquiry
CAR-T-2-M553-BZ T cell Second 8kb Lentiviral VHH-41BB-CD3ζ camelid Inquiry
CAR-T-2-M553-CZ T cell Second 8kb Lentiviral VHH-b2c-CD3ζ camelid Inquiry
CAR-T-3-M303-2BZ T cell Third SM3; HMFG2 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-M303-2XZ T cell Third SM3; HMFG2 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CAR-T-3-M553-2BZ T cell Third 8kb Lentiviral VHH-CD28-41BB-CD3ζ camelid Inquiry
CAR-T-3-M553-2XZ T cell Third 8kb Lentiviral VHH-CD28-OX40-CD3ζ camelid Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

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Australia
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