Mucin-16(MUC16) is also known as cancer/carcinoma antigen 125 (CA125) or FLJ14303, which is mainly expressed in ovarian carcinoma. This protein is encoded by MUC16, providing a protective lubricating barrier against particles and infectious agents at mucosal surfaces. It is a membrane associated mucin that possesses a single transmembrane domain, which is a highly characteristic marker of ovarian carcinomas. Although MUC16 is best known as a marker for ovarian cancer, it also be elevated in other cancers, including endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer.
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