Nef

The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs into exosomes.

Associated Disease
  • HIV-1 infection
Anti-Nef TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C168Z HIV-1 H27-14 Human ~8kb Lentiviral RYPLTFGWCF Non-modified HLA-A24 Inquiry
TCR-C169Z HIV-1 Human ~8kb Lentiviral PDWQNYTPGPG Non-modified HLA-A24 Inquiry
TCR-C170Z HIV-1 Human ~8kb Lentiviral RPMTYKGAL Non-modified HLA-B0702 Inquiry
TCR-C171Z HIV-1 C1-28 Human ~8kb Lentiviral RYPLTFGWCF Non-modified HLA-A24 Inquiry
TCR-C172Z HIV-1 T36-5 Human ~8kb Lentiviral RFPLTFGWCF Non-modified HLA-A24 Inquiry
TCR-L075Z HIV Human 8kb Lentiviral KAAVDLSHFL Non-modified HLA-C*0802 Inquiry
TCR-L076 HIV Human 6700-8070bp retroviral vector KAAVDLSHFL Non-modified TCR HLA-C*0802 Inquiry
TCR-L325 HIV-l HIV-B8-FL8 Human ~8kb Lentiviral FLKEKGGL Non-modified HLA-B8 Inquiry
TCR-L328 HIV-l HIV-B8-FL8-2 Human ~8kb Lentiviral FLKEKGGL Non-modified HLA-B8 Inquiry
TCR-L333 HIV-l HIV-B60-KL9 Human ~8kb Lentiviral KEKGGLEGL Non-modified HLA-B60 Inquiry
TCR-L335 HIV-l HIV-A3-QK10 Human ~8kb Lentiviral QVPLRPMTYK Non-modified HLA-A3/A11 Inquiry
TCR-L336 HIV-l HIV-A3-QK10-2 Human ~8kb Lentiviral QVPLRPMTYK Non-modified HLA-A3/A11 Inquiry
TCR-L337 HIV-l HIV-A3-QK10-3 Human ~8kb Lentiviral QVPLRPMTYK Non-modified HLA-A3/A11 Inquiry
TCR-L338 HIV-l HIV-A3-QK10-4 Human ~8kb Lentiviral QVPLRPMTYK Non-modified HLA-A3/A11 Inquiry
TCR-L339 HIV-l HIV-A3-QK10-5 Human ~8kb Lentiviral QVPLRPMTYK Non-modified HLA-A3/A11 Inquiry
TCR-L340 HIV-l HIV-A3-QK10-6 Human ~8kb Lentiviral QVPLRPMTYK Non-modified HLA-A3 Inquiry
TCR-L341 HIV-l HIV-A3-QK10-7 Human ~8kb Lentiviral QVPLRPMTYK Non-modified HLA-A3 Inquiry
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