NKG2D ligands

The activating receptor NKG2D (natural-killer group 2, member D) and its ligands play an important role in the NK, γδ+ and CD8+ T-cell-mediated immune response to tumors. Ligands for NKG2D are rarely detectable on the surface of healthy cells and tissues, but are frequently expressed by tumor cell lines and in tumor tissues. It is evident that the expression levels of these ligands on target cells have to be tightly regulated to allow immune cell activation against tumors, but at the same time avoid destruction of healthy tissues. Many tumor cell lines and primary tumors from diverse tissue origins express NKG2D ligands. Ovarian carcinoma cells express low amounts of the NKG2D ligands MICA, ULBP1, and ULBP3, whereas ULBP2 was more highly expressed. NKG2D ligands were highly expressed in lymph node metastasis of stage I colorectal cancer samples, but they were expressed in lower amounts in Stage II, III, or IV tumors.

Associated Disease
Anti-NKG2D ligands CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-MZ230 T cell First ~8kb Lentiviral NKG2D receptor-CD3ζ Inquiry
CAR-MZ231 NK cell First ~8kb Retroviral NKG2D receptor-CD3ζ Inquiry
CAR-MZ232 NK cell Second ~8kb Retroviral DAP10-NKG2D receptor-CD3ζ Inquiry
CAR-MZ233 NK cell Second ~8kb Retroviral NKG2D receptor-CD28-CD3ζ Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON