NY-BR-1 is a differentiation antigen of the mammary tissue, since it has been detected solely in the epithelial cells of mammary ducts and lobules, whereas NY-BR-1 expression has not been found in any other tissue. Thus, NY-BR-1 appears to be a breast-specific protein. In preliminary studies, NY-BR-1 mRNA was detected predominantly in breast cancers, and bioinformatic analysis annotated NY-BR-1 as a potential transcription factor. NY-BR-1 protein was shown to be expressed in normal breast epithelia and in the majority of primary breast cancers. NY-BR-1 may represent a potential target antigen for antibody-based therapy in breast cancer. Its frequent expression in breast cancer patients, its cell surface localization and accessibility to the monoclonal antibody mark NY-BR-1 as an attractive target.
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